Novel Synthesis of Polymeric Nanoparticles for Drug Delivery Applications Using Microfluidic Rapid Mixing
نویسندگان
چکیده
We report the use of microfluidic rapid mixing using hydrodynamic flow focusing to control the self-assembly of polymeric nanoparticles (NPs) that can be used for drug delivery. PLGA-PEG polymeric NPs and PLGA-lipid hybrid NPs were synthesized through nanoprecipitation—a process that involves dilution of a block copolymer from a solvent to an anti-solvent resulting in the precipitation of NPs. We demonstrated that by controlling mixing of precursors with anti-solvent (i.e. water), the particle size could be tuned and more homogeneous NPs could be synthesized. This work is the first implementation of nanoprecipitation on a microfluidic platform.
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